In the fast-evolving world of health and wellness, claims about groundbreaking cures often capture public attention. One such claim arises from the YouTube channel “The Diary of a CEO,” featuring Dr. Nathan Bryan, a prominent nitric oxide biochemist. In this episode, Dr. Bryan proposes that a cure for Alzheimer’s disease may already exist, stemming from his extensive research on nitric oxide over an impressive 18-year career. However, such assertions warrant a closer examination. In this blog post, we will delve into the veracity of Dr. Bryan’s claims, analyzing the science behind nitric oxide and its purported benefits in the context of Alzheimer’s treatment. By scrutinizing the evidence and context around these statements, we aim to provide clarity on a topic that is crucial for many families grappling with the challenges of this devastating disease. Join us as we unpack the facts and separate the science from sensationalism.

Find the according transcript on TRNSCRBR

All information as of 04/14/2025

Fact Check Analysis

Claim

This simple molecule nitric oxide gas will eradicate and cure Alzheimer's.

Veracity Rating: 1 out of 4

Facts

The claim that nitric oxide gas will eradicate and cure Alzheimer's disease is an oversimplification of the complex relationship between nitric oxide (NO) and Alzheimer's pathology. While nitric oxide plays a crucial role in various physiological processes, including vasodilation and neurotransmission, its impact on Alzheimer's disease is multifaceted and not entirely straightforward.

### Nitric Oxide's Role in Health and Disease

Nitric oxide is a signaling molecule essential for maintaining vascular health, regulating blood flow, and delivering oxygen to tissues. It is produced by endothelial cells lining blood vessels and plays a key role in vasodilation, which improves blood flow to the brain and other organs[2][3]. Dr. Nathan Bryan and others emphasize that a decline in nitric oxide production is associated with various age-related diseases, including Alzheimer's, diabetes, and cardiovascular conditions[5].

### Nitric Oxide and Alzheimer's Disease

Research indicates that nitric oxide can have both beneficial and detrimental effects on Alzheimer's disease, depending on the context:

1. **Beneficial Effects**: Exercise, which increases nitric oxide production, has been shown to improve blood flow to the brain, potentially slowing cognitive decline in Alzheimer's patients[2][3]. This suggests that maintaining adequate nitric oxide levels could support brain health by enhancing blood flow and oxygen delivery.

2. **Detrimental Effects**: In the context of inflammation, excessive nitric oxide production, particularly through inducible nitric oxide synthase (iNOS), can lead to harmful effects. It can cause S-nitrosylation of proteins like SIRT1, leading to inflammation and cell death, which are associated with Alzheimer's disease progression[1].

### Conclusion

While nitric oxide is crucial for maintaining vascular health and may play a role in mitigating some aspects of Alzheimer's disease, such as improving blood flow, it is not a straightforward cure for Alzheimer's. The disease involves complex pathologies, including protein misfolding, inflammation, and neuronal loss, which cannot be addressed solely by nitric oxide.

In summary, the claim that nitric oxide will eradicate and cure Alzheimer's is an exaggeration. Nitric oxide is important for overall health and may have beneficial effects on Alzheimer's through improved blood flow, but it does not offer a comprehensive solution to the disease's multifaceted pathologies. Further research is needed to fully understand nitric oxide's role in Alzheimer's and to develop effective therapeutic strategies.

**Recommendations for Future Research**:
– Investigate the optimal levels of nitric oxide for therapeutic benefits in Alzheimer's.
– Develop methods to measure nitric oxide levels non-invasively during exercise or other interventions.
– Explore how nitric oxide interacts with other signaling molecules in Alzheimer's pathology.

**Public Health Implications**:
– Educate the public about maintaining nitric oxide levels through lifestyle choices, such as regular exercise and avoiding substances that harm oral microbiomes.
– Support research into nitric oxide-based therapies that target specific aspects of Alzheimer's disease.

Citations

Claim

A loss of nitric oxide production is the earliest event in the onset and progression of age related chronic disease.

Veracity Rating: 3 out of 4

Facts

## Evaluating the Claim: Loss of Nitric Oxide Production as the Earliest Event in Age-Related Chronic Diseases

The claim that a loss of nitric oxide production is the earliest event in the onset and progression of age-related chronic diseases is supported by substantial scientific evidence. Nitric oxide (NO) plays a crucial role in various physiological processes, including vasodilation, anti-inflammatory effects, and neuroprotection[1][3]. Here's a detailed analysis of the claim based on available scientific literature:

### Role of Nitric Oxide in Health

Nitric oxide is a signaling molecule essential for maintaining vascular health, neuronal communication, and immune function[3]. It is produced endogenously by the body and is critical for regulating blood flow and oxygen delivery to tissues[1]. NO's decline with age is associated with several chronic conditions, including cardiovascular disease, cognitive decline, and chronic pain[1][3].

### Decline of Nitric Oxide with Age

Nitric oxide production decreases significantly with age, starting as early as the 40s, with a decline of approximately 10% per decade[1]. This reduction is linked to various age-related health issues, as NO is vital for maintaining vascular tone and preventing inflammation[3][5].

### Connection to Chronic Diseases

The decline in NO production is associated with an increased risk of chronic diseases such as hypertension, diabetes, and Alzheimer's disease[3][5]. For instance, erectile dysfunction, often seen as an early sign of vascular dysfunction, is linked to reduced NO levels and can signal broader cardiovascular issues[2].

### Early Indicators and Precursors

While the claim suggests that NO deficiency is the earliest event in age-related diseases, it is more accurate to say that it is an early indicator or marker of disease. The onset of conditions like erectile dysfunction can be seen as a precursor to more severe vascular and systemic diseases[2].

### Therapeutic and Preventive Strategies

Increasing NO levels through lifestyle modifications (e.g., exercise, diet rich in fruits and vegetables) and supplements (e.g., L-citrulline, beetroot extract) is proposed as a strategy to mitigate age-related health issues[1]. Avoiding substances that inhibit NO production, such as fluoride in toothpaste and antacids, is also recommended[2].

### Conclusion

The claim that a loss of nitric oxide production is an early event in age-related chronic diseases is supported by evidence showing NO's critical role in health and its decline with age. However, it is more nuanced to consider NO deficiency as an early indicator or marker of disease rather than the sole earliest event. Maintaining optimal NO levels is crucial for preventing or mitigating age-related health concerns.

**Evidence Summary:**

– **Nitric Oxide's Role in Health:** NO is essential for vascular health, neuronal communication, and immune function[1][3].
– **Decline with Age:** NO production decreases with age, contributing to chronic diseases[1][3].
– **Connection to Diseases:** Reduced NO levels are linked to hypertension, diabetes, and Alzheimer's disease[3][5].
– **Early Indicators:** Erectile dysfunction can be an early sign of broader vascular issues related to low NO levels[2].
– **Preventive Strategies:** Lifestyle changes and supplements can help maintain NO levels[1].

Citations

Claim

50% of patients treated with prescription medication for hypertension do not respond with better blood pressure because those medications are not targeted toward nitric oxide.

Veracity Rating: 1 out of 4

Facts

## Evaluation of the Claim

The claim suggests that 50% of patients treated with prescription medication for hypertension do not respond with better blood pressure because those medications are not targeted toward nitric oxide. To assess this claim, we need to consider several aspects:

1. **Role of Nitric Oxide in Hypertension**: Nitric oxide (NO) plays a crucial role in vascular health by promoting vasodilation and improving blood flow. Its deficiency can lead to endothelial dysfunction, a key factor in hypertension[1][3].

2. **Effectiveness of Current Hypertension Medications**: Most conventional hypertension medications target various pathways, such as the renin-angiotensin-aldosterone system, calcium channels, or beta-blockers, but not directly nitric oxide production[2].

3. **Nitric Oxide Supplementation and Blood Pressure**: Studies have shown that NO supplementation can lower blood pressure and improve vascular function in patients with hypertension or prehypertension[1][3]. However, these studies do not directly support the claim that 50% of patients do not respond to conventional medications due to a lack of NO targeting.

4. **Response Rates to Hypertension Medications**: The claim that 50% of patients do not respond to conventional hypertension medications because they are not targeted toward nitric oxide lacks specific evidence. While it is true that many patients may not achieve optimal blood pressure control with standard treatments, this is often due to a variety of factors, including medication adherence, lifestyle, and underlying health conditions, rather than a specific lack of NO targeting.

5. **Dr. Nathan Bryan's Research**: Dr. Bryan emphasizes the importance of nitric oxide in health and suggests that many medications do not effectively target NO production. However, his work primarily highlights the benefits of maintaining adequate NO levels rather than providing direct evidence for the claim regarding the response rate to conventional hypertension medications.

### Conclusion

While nitric oxide is crucial for vascular health and its supplementation can be beneficial for blood pressure management, there is no direct evidence to support the specific claim that 50% of patients treated with prescription medication for hypertension do not respond due to a lack of targeting nitric oxide. The effectiveness of hypertension medications varies widely among individuals due to multiple factors, and the role of nitric oxide in this context is an area of ongoing research.

### Recommendations for Future Research

– **Targeted Nitric Oxide Therapies**: Investigate the potential benefits of therapies specifically designed to enhance nitric oxide production or availability in patients with hypertension.
– **Response Rates to Conventional Medications**: Conduct comprehensive studies to determine the actual response rates to conventional hypertension medications and identify factors contributing to non-response.
– **Nitric Oxide and Hypertension Management**: Further explore the role of nitric oxide in hypertension management, including its potential as a therapeutic target for improving blood pressure control.

Citations

Claim

By age 40, we have lost about 50% of our ability to produce nitric oxide in our blood vessels.

Veracity Rating: 3 out of 4

Facts

## Evaluation of the Claim: Nitric Oxide Production Decline with Age

The claim suggests that by age 40, individuals lose about 50% of their ability to produce nitric oxide (NO) in their blood vessels. This assertion is linked to the broader context of aging effects on vascular health and nitric oxide levels. To assess the validity of this claim, we will examine relevant scientific studies and evidence.

### Nitric Oxide Production and Aging

Nitric oxide is a crucial signaling molecule involved in vascular relaxation and maintaining cardiovascular health. It is primarily produced by endothelial nitric oxide synthase (eNOS) in the endothelial cells lining blood vessels. Studies have consistently shown that aging is associated with a decline in endothelial function and a reduction in nitric oxide production.

1. **Endothelial Dysfunction with Aging**: Research indicates that endothelium-dependent vasodilation, which relies on nitric oxide production, declines progressively with age. This decline is evident even in healthy individuals without other cardiovascular risk factors, such as hypertension or diabetes[2][5]. By the fourth decade of life (ages 30-39), significant impairment in endothelium-dependent vasodilation is already observed[5].

2. **Nitric Oxide Bioavailability**: The bioavailability of nitric oxide decreases with age due to several factors, including increased oxidative stress, reduced eNOS activity, and increased levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NOS[3][4]. These changes contribute to reduced nitric oxide production and increased vascular dysfunction.

3. **Quantitative Decline**: While specific studies may not pinpoint a precise 50% decline by age 40, the general consensus is that nitric oxide production and endothelial function significantly decrease with age. For instance, Egashira et al. reported a loss of about 75% of endothelium-derived nitric oxide in the coronary circulation of aging adults compared to young individuals[2].

### Conclusion

The claim that by age 40, we have lost about 50% of our ability to produce nitric oxide in blood vessels aligns with the broader understanding that aging leads to a significant decline in nitric oxide production and endothelial function. However, the exact percentage of decline by age 40 is not universally quantified in scientific literature. The critical takeaway is that aging is associated with a progressive impairment in nitric oxide production, which contributes to various cardiovascular and age-related diseases.

### Recommendations for Future Claims

– **Specificity**: Claims should be supported by specific scientific evidence when possible.
– **Quantification**: Quantitative claims (e.g., "50% decline") should be verified against empirical data.
– **Contextualization**: The broader implications of nitric oxide decline with aging should be emphasized, including its role in cardiovascular health and potential therapeutic targets.

In summary, while the claim about a 50% decline in nitric oxide production by age 40 may not be precisely quantified in all studies, the underlying premise that aging leads to a significant reduction in nitric oxide production is well-supported by scientific evidence.

Citations

Claim

50% of men over the age of 40 self-report erectile dysfunction in the U.S.

Veracity Rating: 1 out of 4

Facts

## Evaluating the Claim: 50% of Men Over 40 Self-Report Erectile Dysfunction in the U.S.

The claim that 50% of men over the age of 40 self-report erectile dysfunction (ED) in the U.S. needs to be evaluated against available epidemiological data and scientific research.

### Prevalence of Erectile Dysfunction

Erectile dysfunction is a common condition that affects men of various ages, but its prevalence increases with age. Studies have shown that ED is more prevalent in older men, with significant correlations to health conditions such as cardiovascular disease, diabetes, and hypertension[4][5].

The **Massachusetts Male Aging Study (MMAS)** found a combined prevalence of mild to moderate ED of 52% in men aged 40–70 years[4]. Another large study reported that the age-standardized prevalence of ED in the U.S. was about 33%, ranging from 25% in men under 59 years to 61% in those over 70 years[5]. However, these figures do not specifically state that 50% of men over 40 self-report ED.

### Nitric Oxide and Erectile Dysfunction

Nitric oxide plays a crucial role in erectile function by facilitating smooth muscle relaxation and vasodilation, which are essential for achieving and maintaining an erection[1][5]. A deficiency in nitric oxide can contribute to ED, especially in cases related to vascular or neurological issues[3][5].

### Cross-Verification with Epidemiological Studies

While the claim of 50% prevalence among men over 40 is not directly supported by the cited studies, it is clear that ED is a significant health issue affecting a substantial portion of the male population, particularly as men age. The relationship between nitric oxide deficiency and ED supports the idea that maintaining healthy nitric oxide levels is important for preventing or managing ED[1][3].

### Conclusion

The claim that 50% of men over 40 self-report erectile dysfunction in the U.S. is not directly verified by the available data. However, ED is indeed a prevalent condition among older men, and its association with nitric oxide deficiency highlights the importance of this molecule in maintaining vascular health and preventing age-related diseases.

### Recommendations for Further Research

1. **Specific Age-Related Prevalence**: Future studies should focus on providing more precise age-related prevalence rates for ED to better understand its impact on different age groups.
2. **Nitric Oxide's Role**: Continued research into the role of nitric oxide in ED and other chronic conditions could provide insights into preventive measures and treatments.
3. **Public Awareness**: Educating the public about the importance of maintaining healthy nitric oxide levels could help in preventing or managing conditions like ED and other age-related diseases.

Citations

Claim

Two out of three Americans have an unsafe elevation in blood pressure.

Veracity Rating: 0 out of 4

Facts

## Evaluating the Claim: Two out of Three Americans Have an Unsafe Elevation in Blood Pressure

The claim that two out of three Americans have an unsafe elevation in blood pressure can be evaluated by examining recent health statistics on hypertension prevalence in the U.S.

### Hypertension Prevalence in the U.S.

According to the Centers for Disease Control and Prevention (CDC), hypertension is a significant health issue in the United States. As of the latest available data, approximately 47% of adults in the U.S. have hypertension, which is defined as a systolic blood pressure of 130 mmHg or higher or a diastolic blood pressure of 80 mmHg or higher. This figure does not support the claim that two out of three Americans have an unsafe elevation in blood pressure.

### Nitric Oxide and Blood Pressure

Dr. Nathan Bryan's research emphasizes the role of nitric oxide in maintaining vascular health and regulating blood pressure. Nitric oxide is crucial for vasodilation, which helps to lower blood pressure by improving blood flow[1][3]. A deficiency in nitric oxide production can contribute to hypertension, among other conditions[3]. However, this does not directly verify the claim about the prevalence of unsafe blood pressure levels.

### Conclusion

Based on available data, the claim that two out of three Americans have an unsafe elevation in blood pressure is not supported. The CDC reports that about 47% of U.S. adults have hypertension, which is a significant health concern but does not align with the claim. Dr. Bryan's work highlights the importance of nitric oxide in vascular health, but it does not provide evidence for the specific prevalence of hypertension claimed.

## References

While specific references to the claim about two-thirds of Americans having unsafe blood pressure levels are not provided in the search results, general information on hypertension prevalence and nitric oxide's role in health can be found in scientific literature and health statistics.

This reference is not provided in the search results but is based on general knowledge of CDC data on hypertension prevalence.

—

## Additional Information on Dr. Nathan Bryan's Work

Dr. Nathan Bryan's research focuses on the critical role of nitric oxide in human health, emphasizing its potential to mitigate diseases such as Alzheimer's and diabetes by improving blood flow, oxygen delivery, and stem cell mobilization[1][3]. He notes that nitric oxide deficiency, which can begin as early as age 30, is linked to various age-related diseases, including hypertension and erectile dysfunction[3]. Bryan advocates for maintaining nitric oxide levels through lifestyle changes and avoiding substances that may deplete it, such as fluoride in oral care products[3]. His personal experiences, including helping his father with non-healing wounds using nitric oxide treatments, have motivated his efforts to raise awareness about the importance of nitric oxide in healthcare[3].

Citations

Claim

Nitric oxide production is necessary for insulin signaling, and loss leads to insulin resistance and diabetes.

Veracity Rating: 3 out of 4

Facts

## Evaluating the Claim: Nitric Oxide Production and Insulin Signaling

The claim that nitric oxide (NO) production is necessary for insulin signaling and that its loss leads to insulin resistance and diabetes requires a thorough examination of scientific evidence. Nitric oxide is a signaling molecule involved in various physiological processes, including vascular health and metabolic regulation.

### Role of Nitric Oxide in Insulin Signaling

Nitric oxide plays a complex role in insulin signaling and glucose metabolism. Research indicates that NO is required for the insulin-sensitizing effects of muscle contraction, suggesting its importance in enhancing insulin sensitivity after exercise[2]. Additionally, NO is involved in the regulation of insulin secretion and synthesis, with both stimulatory and inhibitory effects reported depending on its concentration[3][5].

### Nitric Oxide and Diabetes

Studies suggest that decreased NO bioavailability is associated with the development of type 2 diabetes mellitus (T2DM)[5]. Nitric oxide donors may improve insulin signaling and glucose homeostasis in T2DM and insulin resistance, indicating potential therapeutic applications[5]. However, the role of NO in diabetes is multifaceted, and its effects can vary based on concentration and context.

### Nitric Oxide Deficiency and Metabolic Health

Dr. Nathan Bryan's assertion that nitric oxide deficiency contributes to age-related diseases, including diabetes, aligns with evidence that NO plays a critical role in metabolic health. A deficiency in NO can lead to various health issues, including hypertension and erectile dysfunction[4]. However, while NO is important for overall health, its direct link to eradicating diseases like diabetes requires further research.

### Conclusion

The claim that nitric oxide production is necessary for insulin signaling and that its loss leads to insulin resistance and diabetes is supported by evidence that NO plays a role in insulin sensitivity and glucose metabolism. However, the relationship between NO and diabetes is complex, and more research is needed to fully understand its implications for disease prevention and treatment.

**Key Points:**
– **Nitric Oxide in Insulin Sensitivity:** NO is involved in enhancing insulin sensitivity, particularly after exercise[2].
– **Role in Diabetes:** Decreased NO bioavailability is linked to type 2 diabetes, and NO donors may improve insulin signaling[5].
– **Complexity of NO's Role:** Effects of NO on insulin secretion and synthesis can be both positive and negative, depending on concentration[3].
– **Nitric Oxide Deficiency:** Linked to various health issues, including hypertension and potential metabolic disorders[4].

Overall, while nitric oxide is crucial for metabolic health, its role in preventing or treating diabetes is an area of ongoing research.

Citations

Claim

Alzheimer's has been called diabetes type 3, indicating a connection between insulin resistance and Alzheimer's disease.

Veracity Rating: 3 out of 4

Facts

## Evaluation of the Claim: Alzheimer's as Diabetes Type 3

The claim that Alzheimer's disease is referred to as "diabetes type 3" due to a connection between insulin resistance and Alzheimer's disease is supported by some scientific literature, although it remains a hypothesis rather than a widely accepted clinical diagnosis.

### Background on Type 3 Diabetes

Type 3 diabetes is a term used by some researchers to describe the hypothesis that insulin resistance in the brain contributes to Alzheimer's disease[4]. This concept suggests that Alzheimer's could be viewed as a form of diabetes affecting the brain, where neurons become resistant to insulin, impairing cognitive functions like memory and learning[3][4].

### Connection Between Insulin Resistance and Alzheimer's

Research indicates that insulin resistance plays a significant role in Alzheimer's disease. Studies have shown that insulin resistance in the brain can lead to cognitive decline and is linked to the pathogenesis of Alzheimer's[5]. For instance, defects in insulin receptors at the blood-brain barrier have been associated with brain insulin resistance in Alzheimer's patients[1]. Additionally, the APOE4 gene, a major genetic risk factor for Alzheimer's, has been found to impair insulin signaling in the brain[2].

### Evidence Supporting the Hypothesis

1. **Insulin Receptors in the Brain**: Research has identified that insulin receptors, particularly the INSRα-B isoform, are predominantly located in cerebral microvessels rather than neurons. The loss of these receptors in Alzheimer's patients contributes to brain insulin resistance and cognitive decline[1].

2. **APOE4 Gene Impact**: The APOE4 gene variant disrupts insulin signaling by competing with insulin for receptor binding, leading to insulin resistance and contributing to Alzheimer's pathogenesis[2].

3. **Insulin Resistance Mechanisms**: Insulin resistance exacerbates Alzheimer's disease by promoting amyloid beta accumulation and tau hyperphosphorylation, creating a feed-forward loop that worsens both conditions[5].

### Limitations and Controversies

While there is evidence supporting the link between insulin resistance and Alzheimer's, "type 3 diabetes" is not an officially recognized medical term by national health organizations or the American Diabetes Association[4]. More research is needed to fully understand this connection and to determine if managing insulin resistance could impact Alzheimer's disease progression.

### Conclusion

The claim that Alzheimer's disease is sometimes referred to as "diabetes type 3" due to its connection with insulin resistance is supported by scientific hypotheses and research findings. However, it remains a speculative concept within the medical community, and further investigation is necessary to establish it as a recognized clinical entity.

—

Regarding Dr. Nathan Bryan's claims about nitric oxide, while his research highlights the importance of nitric oxide in human health, it does not directly relate to the connection between insulin resistance and Alzheimer's disease. Nitric oxide's role in vascular health and potential implications for age-related diseases are separate from the specific link between insulin resistance and Alzheimer's pathogenesis.

Citations

Claim

By age 70 to 80, nitric oxide levels in blood vessels can be 75% lower than in young adults.

Veracity Rating: 4 out of 4

Facts

## Evaluation of the Claim: Nitric Oxide Levels in Blood Vessels by Age 70 to 80

The claim that by age 70 to 80, nitric oxide levels in blood vessels can be 75% lower than in young adults is supported by scientific evidence. This reduction is attributed to the natural aging process, which affects the endothelium's ability to produce nitric oxide (NO), a crucial molecule for vascular health.

### Evidence Supporting the Claim

1. **Endothelial Dysfunction with Aging**: Studies have consistently shown that aging leads to endothelial dysfunction, which impairs the production of endothelium-derived nitric oxide (ED-NO) [1][3][5]. This dysfunction is a key factor in the decline of nitric oxide levels with age.

2. **Nitric Oxide Reduction in Older Adults**: Research indicates that the bioavailability of nitric oxide decreases significantly as people age. For instance, a study found that in the coronary circulation of aging adults, there was a loss of approximately 75% of endothelium-derived nitric oxide compared to young adults [3]. This aligns with the claim.

3. **Impact on Vascular Health**: The decline in nitric oxide levels contributes to various age-related vascular issues, including hypertension and atherosclerosis, by impairing vasodilation and increasing oxidative stress [1][2][3].

### Additional Context

– **Dr. Nathan Bryan's Research**: While Dr. Bryan emphasizes the importance of nitric oxide in preventing diseases like Alzheimer's and diabetes, his specific findings about nitric oxide deficiency starting as early as age 30 highlight the progressive nature of this decline. However, the specific claim about a 75% reduction by age 70 to 80 is supported by studies on endothelial function and nitric oxide production in older adults [3].

– **Public Health Implications**: Maintaining healthy nitric oxide levels through lifestyle changes and awareness about environmental factors (e.g., avoiding certain substances) is crucial for mitigating age-related diseases [1][3].

### Conclusion

The claim that nitric oxide levels in blood vessels can be 75% lower by age 70 to 80 compared to young adults is supported by scientific evidence. This reduction is linked to endothelial dysfunction and decreased nitric oxide production with aging, contributing to various cardiovascular and age-related health issues.

Citations

Claim

The U.S. spends nearly 20% of its GDP on healthcare but ranks last overall on health outcomes among high-income countries.

Veracity Rating: 3 out of 4

Facts

To evaluate the claim that the U.S. spends nearly 20% of its GDP on healthcare but ranks last overall on health outcomes among high-income countries, we need to examine two key components: healthcare spending as a percentage of GDP and health outcomes compared to other high-income countries.

## Healthcare Spending as a Percentage of GDP

The claim states that the U.S. spends nearly 20% of its GDP on healthcare. As of 2023, the U.S. spent approximately 17.6% of its GDP on healthcare, according to projections from the Centers for Medicare & Medicaid Services (CMS)[1][3]. However, it is projected to reach nearly 20% by 2032[1]. This aligns with the general trend of increasing healthcare spending in the U.S.

## Health Outcomes Compared to Other High-Income Countries

The claim also asserts that the U.S. ranks last overall on health outcomes among high-income countries. A report from the Commonwealth Fund supports this assertion, indicating that among 10 high-income nations, the U.S. has the worst health outcomes despite spending the most on healthcare[4]. The U.S. has lower life expectancy and higher rates of preventable deaths compared to peer countries[4]. Additionally, the U.S. ranks poorly in access to care and health equity[4].

## Conclusion

While the U.S. does not yet spend nearly 20% of its GDP on healthcare (it was about 17.6% in 2023), projections indicate it will reach this level by 2032[1]. The claim about poor health outcomes is supported by evidence showing that despite high spending, the U.S. performs poorly in health outcomes compared to other high-income countries[4]. Thus, the claim is partially accurate regarding current spending levels but accurate regarding health outcomes.

### Evidence Summary:
– **Healthcare Spending**: The U.S. currently spends about 17.6% of its GDP on healthcare, projected to increase to nearly 20% by 2032[1][3].
– **Health Outcomes**: The U.S. ranks poorly in health outcomes among high-income countries, despite being the largest spender on healthcare[4].

Citations

Claim

Americans are spending about 13 years of their life living with disease, which is significantly higher than many other high-income Western countries.

Veracity Rating: 1 out of 4

Facts

## Evaluating the Claim: Americans Spend About 13 Years of Their Life Living with Disease

The claim that Americans spend about 13 years of their life living with disease is not directly supported by the provided search results. However, it can be evaluated in the context of broader health statistics and comparisons with other high-income Western countries.

### Health Statistics and Comparisons

1. **Health Outcomes in the U.S.**: The U.S. experiences poorer health outcomes compared to other high-income countries. Americans are more likely to die younger and from avoidable causes than residents of peer nations[2]. This suggests that the U.S. population might indeed spend a significant portion of their lives dealing with health issues, but specific data on the exact duration is not provided in the search results.

2. **Healthcare Spending and Efficiency**: The U.S. spends a significant portion of its GDP on healthcare, yet its health outcomes are often inferior to those of other developed countries[4]. This inefficiency could contribute to a longer period of living with disease due to less effective management and prevention strategies.

3. **Nitric Oxide and Health**: Dr. Nathan Bryan's research highlights the importance of nitric oxide in preventing age-related diseases such as Alzheimer's and diabetes[1][5]. A deficiency in nitric oxide, starting as early as age 30, is linked to various chronic conditions, which could contribute to a longer period of living with disease. However, this does not directly quantify the duration of living with disease.

### Conclusion

While the exact claim of Americans spending about 13 years of their life living with disease is not directly supported by the provided sources, it is clear that the U.S. faces significant health challenges compared to other high-income countries. The emphasis on nitric oxide's role in health suggests that addressing deficiencies in this molecule could improve health outcomes, potentially reducing the duration of living with disease.

To validate the specific claim, data from organizations like the World Health Organization (WHO) or the Centers for Disease Control and Prevention (CDC) would be necessary. These organizations track health expectancy and disease prevalence, which could provide insights into how much of their lives Americans spend dealing with health issues.

### Recommendations for Further Research

– **Health Expectancy Data**: Utilize health expectancy data from reputable sources like the WHO or CDC to assess the average years Americans spend living with disease.
– **Nitric Oxide Research**: Further investigate Dr. Nathan Bryan's research and similar studies on nitric oxide's impact on chronic diseases to understand its potential in improving health span.
– **Comparative Health Studies**: Conduct comparative analyses with other high-income countries to identify factors contributing to differences in health outcomes and disease prevalence.

Citations

Claim

Nitric oxide is the foundational longevity molecule because it signals the body to mobilize and differentiate stem cells, activates telomerase, and signals cells to increase mitochondrial production and efficiency.

Veracity Rating: 1 out of 4

Facts

## Evaluating the Claim: Nitric Oxide as the Foundational Longevity Molecule

The claim that nitric oxide (NO) is the foundational longevity molecule because it signals the body to mobilize and differentiate stem cells, activates telomerase, and signals cells to increase mitochondrial production and efficiency requires a thorough examination of scientific evidence.

### Nitric Oxide's Role in Cellular Functions

1. **Signaling and Mobilization of Stem Cells**: While nitric oxide is known as a signaling molecule involved in various physiological processes, including vascular homeostasis and immune response, there is limited direct evidence linking it specifically to the mobilization and differentiation of stem cells in the context of aging and longevity[2][3]. However, its role in cellular signaling could potentially influence stem cell behavior indirectly.

2. **Activation of Telomerase**: There is no direct scientific evidence that nitric oxide activates telomerase. Telomerase activation is more commonly associated with other factors, such as telomere length maintenance mechanisms[5].

3. **Mitochondrial Production and Efficiency**: Nitric oxide does play a role in regulating mitochondrial function and energy metabolism. It can increase cellular and whole-body energy production by enhancing mitochondrial biogenesis and function[2]. However, the claim that it specifically signals cells to increase mitochondrial production and efficiency in the context of longevity is not fully supported by direct evidence.

### Nitric Oxide's General Role in Longevity and Health

Nitric oxide is indeed crucial for cardiovascular health, immune function, and metabolic performance[3]. It helps relax and expand arteries, improving blood flow and oxygen delivery[3]. Its production decreases with age, contributing to various age-related conditions such as hypertension and decreased exercise capacity[3]. However, the specific mechanisms by which it might influence longevity, such as stem cell mobilization or telomerase activation, are not well-documented in the scientific literature.

### Dr. Nathan Bryan's Claims

Dr. Nathan Bryan emphasizes nitric oxide's role in health, linking its deficiency to age-related diseases. While his work highlights the importance of nitric oxide in vascular health and potentially in stem cell mobilization, the specific claims about telomerase activation and detailed mechanisms of stem cell differentiation are not widely supported by existing scientific literature.

### Conclusion

While nitric oxide is a critical molecule for health and longevity, the specific claims about its role in mobilizing and differentiating stem cells, activating telomerase, and signaling for increased mitochondrial production are not fully supported by current scientific evidence. Nitric oxide's importance in cardiovascular health, immune function, and metabolic regulation is well-established, but its direct influence on stem cells and telomerase in the context of aging requires further research for validation.

**Recommendations for Future Research**:
– Investigate the direct effects of nitric oxide on stem cell mobilization and differentiation.
– Examine the potential role of nitric oxide in telomerase activation.
– Further elucidate how nitric oxide influences mitochondrial biogenesis and efficiency in aging models.

**Current Evidence Base**:
– Nitric oxide's role in vascular health and metabolism is well-documented[2][3].
– Its decline with age contributes to various health issues[3].
– Direct evidence linking nitric oxide to stem cell mobilization, telomerase activation, and specific mitochondrial signaling in longevity is lacking.

Citations

Claim

Shorter telomeres are associated with shorter lifespans and higher death rates.

Veracity Rating: 3 out of 4

Facts

## Evaluation of the Claim: "Shorter Telomeres Are Associated with Shorter Lifespans and Higher Death Rates"

The claim that shorter telomeres are associated with shorter lifespans and higher death rates can be evaluated through scientific research on telomere biology and its implications for human health and longevity.

### Telomeres and Aging

Telomeres are protective caps at the ends of chromosomes that shorten with each cell division and as we age. This shortening is a hallmark of cellular aging and has been linked to various age-related diseases, including cardiovascular disease, cancer, and dementia[1][2].

### Association with Mortality

Numerous studies have found associations between shorter telomeres and increased mortality. For example, individuals with the shortest telomeres have been shown to have a higher risk of all-cause mortality compared to those with longer telomeres. A meta-analysis involving over 121,000 participants found that individuals in the shortest telomere length quartile had a 26% higher risk of all-cause mortality than those in the longest quartile[1]. Another study indicated that short baseline leukocyte telomere length (LTL) was associated with a higher risk of mortality from cardiovascular disease[1].

### Telomere Length and Age-Related Diseases

Telomere shortening contributes to genomic instability and modulates gene expression, which can lead to age-related diseases[2]. Associations have been observed between short telomeres and diseases like cardiovascular disease, type 2 diabetes, and cancer[2][4]. However, the relationship between telomere length and mortality is not consistent across all studies, with some finding no association, particularly in older populations[1][5].

### Genetic and Longevity Research

Genetic studies suggest that telomere length is heritable and influenced by lifestyle factors such as stress, diet, and physical activity[2]. Longevity research indicates that while initial telomere length does not predict species lifespan, the rate of telomere shortening is a significant predictor of lifespan across species[3]. In humans, reaching a "telomeric brink" (critically short telomeres) is associated with a high risk of mortality, suggesting a biological limit to human lifespan[4].

### Conclusion

The claim that shorter telomeres are associated with shorter lifespans and higher death rates is supported by substantial scientific evidence. Telomere shortening is linked to increased mortality and age-related diseases, although the relationship is complex and influenced by various factors. While not all studies confirm this association, particularly in older populations, the overall consensus supports the claim.

### Additional Context: Nitric Oxide and Telomeres

While Dr. Nathan Bryan's research on nitric oxide highlights its importance in human health, there is no direct link mentioned between nitric oxide levels and telomere length in the provided information. However, maintaining optimal health through factors like nitric oxide could indirectly influence telomere health by reducing oxidative stress and inflammation, which are known to accelerate telomere shortening[2].

In summary, the claim about telomeres and lifespan is supported by scientific evidence, but the relationship is nuanced and influenced by multiple factors.

Citations

Claim

The microbiome plays a crucial role in human health, and disruptions to it can lead to systemic diseases.

Veracity Rating: 4 out of 4

Facts

## Evaluation of the Claim: The Microbiome Plays a Crucial Role in Human Health, and Disruptions to It Can Lead to Systemic Diseases

The claim that the microbiome is crucial for human health and that disruptions to it can lead to systemic diseases is supported by substantial scientific evidence. Here's a detailed analysis based on reliable sources:

### The Role of the Microbiome in Human Health

1. **Microbiome Composition and Function**: The human microbiome consists of trillions of microorganisms, including bacteria, fungi, viruses, and other microbes, which are essential for various bodily functions. These microbes are involved in digestion, vitamin synthesis, and immune system modulation[1][3].

2. **Impact on Immune System**: The microbiome plays a significant role in stimulating the immune system and protecting against pathogens. It helps in distinguishing between beneficial and harmful bacteria, which is crucial for immune system maturation[3][4].

3. **Metabolic and Systemic Effects**: The gut microbiome influences metabolism, barrier homeostasis, and inflammation, impacting overall health. It is considered a vital organ due to its extensive interactions with other bodily systems[3][5].

### Disruptions to the Microbiome and Systemic Diseases

1. **Dysbiosis and Disease**: Dysbiosis, or an imbalance in the microbiome, is linked to various diseases, including gastrointestinal disorders, autoimmune conditions, obesity, diabetes, and cardiovascular diseases[2][3]. Dysbiosis can result from factors like diet changes, antibiotic use, and environmental exposures[2][3].

2. **Evidence from Research**: Studies have shown that alterations in the gut microbiota are associated with systemic diseases. For example, research on gut microbiota in obesity and diabetes highlights the role of microbiome imbalance in metabolic disorders[2][3].

3. **Therapeutic Interventions**: Microbiome-based treatments, such as probiotics and fecal transplants, are being explored for their potential to restore balance and mitigate disease symptoms[2][4].

### Conclusion

The claim that the microbiome is crucial for human health and that disruptions to it can lead to systemic diseases is well-supported by scientific evidence. The microbiome's role in digestion, immune function, and metabolism underscores its importance in maintaining health. Dysbiosis, or microbial imbalance, is a significant risk factor for various systemic diseases, emphasizing the need for further research into microbiome-based interventions.

—

### Additional Information on Nitric Oxide and the Microbiome

While Dr. Nathan Bryan's research on nitric oxide highlights its importance in human health, particularly in regulating blood flow and oxygen delivery, it does not directly address the microbiome's role in health and disease. However, his mention of oral microbiome damage due to substances like fluoride in toothpaste indirectly relates to microbiome health. Maintaining a healthy microbiome is crucial for overall well-being, and factors affecting the microbiome, such as diet and environmental exposures, can have broader implications for health.

### References

[1] The Nutrition Source. *The Microbiome*. Harvard School of Public Health.
[2] *Exploration of the Human Microbiome's Role in Health and Disease*. Microbiology Journal.
[3] *Human gut microbiota in health and disease*. Frontiers in Microbiology.
[4] *The Interplay between the Gut Microbiome and the Immune System*. PMC.
[5] *How the microbiome affects your health, explained*. UChicago News.

Citations

Claim

Children who grow up in rural areas, exposed to dirt and bacteria, tend to have lower incidences of cardiovascular disease and diabetes later in life.

Veracity Rating: 2 out of 4

Facts

## Claim Evaluation: Children Exposed to Dirt and Bacteria in Rural Areas Have Lower Incidences of Cardiovascular Disease and Diabetes

The claim that children who grow up in rural areas, exposed to dirt and bacteria, tend to have lower incidences of cardiovascular disease and diabetes later in life can be partially supported by the hygiene hypothesis. However, direct evidence linking rural upbringing specifically to reduced cardiovascular disease and diabetes is limited.

### The Hygiene Hypothesis

The hygiene hypothesis suggests that early exposure to certain microorganisms can protect against allergies and autoimmune diseases by properly tuning the immune system[1][3]. This hypothesis is often extended to include other conditions, but its primary focus is on allergies and autoimmune diseases rather than cardiovascular disease or diabetes directly.

### Epidemiological Evidence

Epidemiological studies have shown that individuals from less affluent or rural areas may have different microbiome compositions and potentially lower rates of certain autoimmune diseases compared to those in more affluent or urban settings[1][5]. However, these studies primarily focus on allergies and autoimmune diseases rather than cardiovascular disease or diabetes.

### Cardiovascular Disease and Diabetes

While there is substantial research on the risk factors for cardiovascular disease and diabetes, such as diet, lifestyle, and socioeconomic status[2][4], there is limited direct evidence linking rural upbringing and exposure to dirt and bacteria specifically to lower incidences of these conditions. Factors such as physical activity, diet, and access to healthcare in rural areas can influence the risk of developing cardiovascular disease and diabetes[4].

### Nitric Oxide and Health

Dr. Nathan Bryan's research on nitric oxide highlights its importance in human health, including its role in regulating blood flow and oxygen delivery, which could impact cardiovascular health. However, his work does not directly address the claim about rural upbringing and exposure to dirt and bacteria.

### Conclusion

While the hygiene hypothesis provides some support for the idea that early exposure to microorganisms can influence health outcomes, the specific claim about lower incidences of cardiovascular disease and diabetes in individuals raised in rural areas is not strongly supported by direct scientific evidence. Further research is needed to explore these potential connections.

## Recommendations for Future Research

1. **Longitudinal Studies**: Conduct longitudinal studies to track health outcomes in children raised in rural versus urban environments, focusing on cardiovascular disease and diabetes.
2. **Microbiome Analysis**: Analyze the microbiome composition of individuals from different environments to understand its impact on health.
3. **Nitric Oxide Research**: Investigate how nitric oxide levels are influenced by environmental factors and their potential role in preventing age-related diseases.

By pursuing these avenues, researchers can better understand the relationships between environmental exposure, microbiome composition, and long-term health outcomes.

Citations

Claim

Fluoride has been reported to lower IQ in kids by as much as seven points and is considered a neurotoxin.

Veracity Rating: 3 out of 4

Facts

## Evaluating the Claim: Fluoride's Impact on Children's IQ

The claim that fluoride can lower IQ in children by as much as seven points and is considered a neurotoxin requires a thorough examination of scientific evidence. Here's a detailed analysis based on available research:

### Evidence from Studies

1. **Harvard Study (2012):** A meta-analysis conducted by researchers from Harvard School of Public Health and China Medical University combined 27 studies, mostly from China, and found strong indications that fluoride may adversely affect cognitive development in children. The analysis suggested an average loss in IQ of about seven points for children exposed to high fluoride levels in drinking water[1].

2. **Recent Reviews and Studies:** Subsequent reviews and studies have supported the notion that elevated fluoride exposure during early development can result in cognitive deficits. For instance, a 2019 review highlighted that fourteen recent cross-sectional studies from areas with high fluoride concentrations in groundwater supported previous findings of cognitive deficits in children[2]. Additionally, prospective studies from Mexico and Canada showed negative associations between early-life fluoride exposure and children's cognitive test performance[2].

3. **National Toxicology Program (NTP) Findings:** The NTP concluded with moderate confidence that higher levels of fluoride exposure (above 1.5 mg/L) are associated with lower IQ in children. However, there was insufficient data to determine if lower fluoride levels, such as the 0.7 mg/L recommended in the U.S., have negative effects on children's IQ[3].

### Conclusion

The claim that fluoride can lower IQ in children by as much as seven points is supported by some studies, particularly those from areas with high fluoride exposure. However, the evidence is not universally accepted, and more research is needed to fully understand the effects of fluoride at lower concentrations commonly found in community water supplies. Fluoride is not universally classified as a neurotoxin in the same category as lead or mercury, but there is evidence suggesting potential neurotoxic effects at high exposure levels.

### Nitric Oxide and Fluoride

Regarding Dr. Nathan Bryan's claims about nitric oxide and fluoride, while fluoride exposure is a concern for neurodevelopmental effects, the specific link between fluoride in toothpaste and mouthwash and nitric oxide depletion is not directly addressed in the major scientific reviews on fluoride neurotoxicity. Dr. Bryan's advocacy for maintaining nitric oxide levels highlights the importance of this molecule in health, but the connection to fluoride specifically in this context requires further investigation.

In summary, while there is evidence suggesting that high levels of fluoride exposure may be associated with cognitive deficits in children, the claim about fluoride being a neurotoxin and lowering IQ by seven points needs to be understood within the context of varying exposure levels and ongoing research.

Citations

Claim

100% of people with primary tumors have dental infections.

Veracity Rating: 0 out of 4

Facts

## Evaluation of the Claim: "100% of people with primary tumors have dental infections"

The claim that "100% of people with primary tumors have dental infections" is not supported by scientific evidence. While there is a significant prevalence of oral infections among cancer patients, the rate is not universal.

### Prevalence of Oral Infections in Cancer Patients

A study investigating oral infections in patients with advanced malignancies found that oral infections were prevalent in 46% of all cancer patients, with the highest rates in those with oral and maxillofacial tumors (67%) and hematological malignancies (58.6%)[1]. This indicates that while oral infections are common among cancer patients, they do not occur in every individual with primary tumors.

### Association Between Dental Infections and Cancer

Research suggests that chronic dental infections may be associated with an increased risk of cancer, as they can lead to systemic inflammation[3]. However, this does not imply that all individuals with primary tumors have dental infections. The relationship between dental health and cancer is complex and involves multiple factors, including the type of cancer, treatment modalities, and individual health conditions[1][3].

### Conclusion

Based on the available evidence, the claim that "100% of people with primary tumors have dental infections" is **false**. While oral infections are prevalent among certain groups of cancer patients, they are not universal. The relationship between dental health and cancer is multifaceted and requires further research to fully understand the connections and risk factors involved.

### References

[1] Investigation of the oral infections and manifestations seen in patients with advanced malignancies.
[3] History of Dental Infections Associates with Cancer in Periodontally Healthy Subjects.

Citations

Claim

Using mouthwash can cause blood pressure to increase after seven days.

Veracity Rating: 3 out of 4

Facts

## Evaluating the Claim: "Using mouthwash can cause blood pressure to increase after seven days."

The claim suggests a causal relationship between mouthwash use and an increase in blood pressure. To assess this claim, we need to examine the available scientific evidence, particularly focusing on studies that investigate the effects of mouthwash on blood pressure.

### Evidence from Studies

1. **Nitric Oxide and Blood Pressure Regulation**: Nitric oxide (NO) plays a crucial role in regulating blood pressure by promoting blood vessel dilation. Research indicates that antibacterial mouthwashes can reduce the population of oral bacteria that convert nitrates to nitrites, which are essential for NO production. This reduction in NO bioavailability can potentially lead to increased blood pressure[1][3].

2. **Chlorhexidine Mouthwash**: A study involving chlorhexidine, a common antiseptic in mouthwashes, found that twice-daily use for one week significantly increased systolic blood pressure in healthy individuals. This effect was attributed to the reduction in nitrate-reducing bacteria in the oral cavity[3].

3. **Long-term Use and Hypertension Risk**: Another study from the San Juan Overweight Adults Longitudinal Study (SOALS) observed that frequent use of over-the-counter mouthwash (twice daily or more) was associated with a higher incidence of hypertension over a three-year period. This association persisted even after controlling for major risk factors for hypertension[1][4].

### Meta-Analysis and Systematic Reviews

A recent systematic review and meta-analysis found no statistically significant increase in systolic, diastolic, or mean arterial pressure due to mouthwash use. However, this conclusion should be interpreted cautiously due to the variability among the studies included[5].

### Conclusion

While there is evidence suggesting that frequent use of antibacterial mouthwashes can lead to increased blood pressure by reducing nitric oxide production, the claim that mouthwash use causes blood pressure to increase after seven days is partially supported. The study involving chlorhexidine showed an increase in blood pressure after one week of use[3]. However, not all studies demonstrate a consistent effect, and more research is needed to establish a definitive causal relationship[5].

In summary, the claim has some scientific backing, particularly concerning the impact of certain mouthwash ingredients on nitric oxide levels and blood pressure. However, the evidence is not uniform across all studies, and further research is necessary to confirm the specific time frame and causal relationship proposed by the claim.

Citations

Claim

If you use mouthwash, you lose the cardioprotective benefits of exercise.

Veracity Rating: 4 out of 4

Facts

## Claim Evaluation: "If you use mouthwash, you lose the cardioprotective benefits of exercise."

The claim suggests that using mouthwash can negate the cardioprotective benefits of exercise, particularly those related to blood pressure reduction. This assertion is supported by scientific studies that highlight the role of the oral microbiome in cardiovascular health.

### Key Findings and Evidence

1. **Oral Microbiome and Nitric Oxide Production**: Research indicates that oral bacteria play a crucial role in converting dietary nitrates into nitrite, which is then converted into nitric oxide (NO) in the body. NO is essential for vasodilation, improving blood flow and lowering blood pressure[1][3]. Dr. Nathan Bryan's work emphasizes the importance of NO in human health, including its role in regulating blood flow and preventing chronic conditions like hypertension[5].

2. **Impact of Mouthwash on Oral Microbiome**: Studies have shown that antibacterial mouthwashes, such as those containing chlorhexidine, can disrupt the oral microbiome by killing beneficial bacteria. This disruption reduces the production of nitrite and subsequently NO, which is critical for maintaining cardiovascular health[1][2][4].

3. **Exercise and Blood Pressure Reduction**: Exercise is known to lower blood pressure, partly due to increased NO production. However, using antibacterial mouthwash after exercise has been shown to significantly reduce this blood pressure-lowering effect. A study published in *Free Radical Biology and Medicine* found that the use of antibacterial mouthwash diminished the blood pressure-lowering effect of exercise by more than 60% during the first hour after exercise[1][3][5].

4. **Long-term Effects and Restoration of Oral Microbiome**: While there is evidence that the nitrate-reducing function of oral bacteria can be restored after mouthwash use, the exact timeline for full recovery of the oral microbiome is not well understood[2]. Further research is needed to determine how long it takes for the microbiome to return to its baseline state after disruption by mouthwash.

### Conclusion

The claim that using mouthwash can negate the cardioprotective benefits of exercise, specifically the blood pressure-lowering effect, is supported by scientific evidence. The disruption of the oral microbiome by antibacterial mouthwashes reduces NO production, which is crucial for vasodilation and maintaining cardiovascular health benefits associated with exercise. However, it is essential to note that this does not mean all benefits of exercise are lost; other cardiovascular benefits, such as improved heart rate response and better blood flow, remain unaffected by mouthwash use[5].

### Recommendations

– **Further Research**: More studies are needed to fully understand the long-term effects of mouthwash on the oral microbiome and its implications for cardiovascular health.
– **Public Awareness**: Educating the public about the importance of maintaining a healthy oral microbiome and the potential impacts of antibacterial mouthwashes on NO production and cardiovascular health is crucial.
– **Clinical Practice**: Health professionals should consider the oral environment when recommending interventions for high blood pressure, potentially advising against unnecessary use of antibacterial mouthwashes unless medically indicated[1][5].

Citations

Claim

Without the right oral bacteria, you get zero benefits from a plant-based diet in terms of blood pressure-lowering effects.

Veracity Rating: 1 out of 4

Facts

## Evaluation of the Claim

The claim suggests that without the right oral bacteria, one cannot benefit from a plant-based diet in terms of lowering blood pressure. This assertion connects gut microbiome health with dietary benefits and implies a link between oral health, the microbiome, and blood pressure regulation. To evaluate this claim, we need to examine the roles of the gut microbiome, oral health, and nitric oxide in blood pressure regulation.

### Role of the Gut Microbiome

The gut microbiome plays a crucial role in metabolic health, including blood pressure regulation. Plant-based diets have been shown to positively influence the gut microbiota by increasing diversity and promoting beneficial bacteria, which can lead to improved metabolic outcomes, including lower blood pressure[2][3]. However, the claim specifically mentions oral bacteria, which are part of the broader oral microbiome rather than the gut microbiome.

### Oral Health and Nitric Oxide

Dr. Nathan Bryan's research emphasizes the importance of nitric oxide (NO) in health, including its role in regulating blood flow and oxygen delivery[3]. Nitric oxide is indeed crucial for vascular health, and its deficiency can lead to conditions like hypertension[3]. However, the connection between oral bacteria and nitric oxide production is less clear. While oral health can impact systemic health, the direct link between oral bacteria and the benefits of a plant-based diet on blood pressure is not well-established in scientific literature.

### Evidence and Conclusion

There is substantial evidence supporting the benefits of plant-based diets on blood pressure, primarily through mechanisms involving the gut microbiome, improved vasodilation, and reduced inflammation[1][3][5]. However, the specific claim that oral bacteria are essential for these benefits lacks direct scientific support. While oral health is important for overall health, the primary benefits of plant-based diets on blood pressure are more closely related to gut health and systemic factors like nitric oxide production rather than oral microbiome composition.

In summary, while the gut microbiome and nitric oxide play significant roles in blood pressure regulation, the claim that oral bacteria are necessary for the blood pressure-lowering effects of a plant-based diet is not supported by current scientific evidence. The benefits of plant-based diets on blood pressure are well-documented and primarily attributed to factors other than oral bacteria.

### Recommendations for Future Research

1. **Investigate the Direct Link Between Oral Bacteria and Nitric Oxide Production**: Studies should explore how oral bacteria might influence nitric oxide levels and, subsequently, blood pressure.
2. **Examine the Impact of Oral Health on Gut Microbiome Diversity**: Research could investigate whether oral health affects gut microbiota composition and function, potentially influencing blood pressure.
3. **Conduct Interventional Studies**: Clinical trials examining the effects of oral health interventions on blood pressure in individuals following plant-based diets would provide valuable insights.

Citations

Claim

Research shows a link between oral health and cancer, specifically identifying bacteria linked to a high risk of head and neck cancers.

Veracity Rating: 4 out of 4

Facts

## Evaluating the Claim: Link Between Oral Health and Head and Neck Cancer

The claim that research shows a link between oral health and cancer, specifically identifying bacteria linked to a high risk of head and neck cancers, is supported by recent scientific studies.

### Evidence Supporting the Claim

1. **Oral Bacteria and Head and Neck Cancer**: A study published in *JAMA Oncology* identified 13 species of oral bacteria associated with an increased risk of developing head and neck squamous cell carcinoma (HNSCC)[1][3]. These bacteria include *Prevotella salivae*, *Streptococcus sanguinis*, and species from the beta and gamma Proteobacteria[1]. The study found that a combination of these bacteria and others linked to gum disease increased the risk by 50%[1][5].

2. **Oral Microbiome and Cancer Risk**: The study analyzed saliva samples from over 159,000 participants and found that certain oral bacteria were differentially associated with HNSCC risk[3]. While overall microbiome diversity did not correlate with cancer risk, specific bacterial species did[1].

3. **Implications for Prevention**: Researchers suggest that these bacteria could serve as biomarkers for identifying individuals at high risk of HNSCC, potentially leading to personalized prevention strategies[1][4]. Practicing good oral hygiene, such as brushing and flossing, may help reduce this risk[2][4].

### Conclusion

The claim is supported by scientific evidence indicating a link between specific oral bacteria and an increased risk of head and neck cancers. However, further research is needed to establish a direct cause-and-effect relationship and to explore how these bacteria contribute to cancer development[2][5].

### Additional Context: Nitric Oxide and Oral Health

While Dr. Nathan Bryan's research on nitric oxide highlights its importance in human health, including its potential impact on oral health by affecting the oral microbiome, this aspect does not directly relate to the specific claim about oral bacteria and head and neck cancer. However, maintaining a healthy oral microbiome is crucial for overall health, and factors affecting it, such as nitric oxide levels, could have broader implications for health outcomes.

—

**References:**

[1] Inside Precision Medicine. (2024, September 26). Oral Bacteria Linked with Head and Neck Cancer.
[2] Minnesota Oncology. Link Between Head and Neck Cancer and Dental Bacteria.
[3] ADA News. Oral microbiota may be implicated in head and neck cancer development.
[4] Euronews. (2024, September 27). Scientists discover link between bacteria in the mouth and head and neck cancers.
[5] NYU Langone Health. (2024, September 26). Bacteria Involved in Gum Disease Linked to Increased Risk of Head and Neck Cancer.
Note: The specific reference to Dr. Nathan Bryan's work on nitric oxide is not directly supported by the provided search results but is mentioned in the query context.

Citations

Claim

The future of medicine and healthcare will depend on nitric oxide product technology.

Veracity Rating: 3 out of 4

Facts

## Evaluating the Claim: The Future of Medicine and Healthcare Will Depend on Nitric Oxide Product Technology

The claim that the future of medicine and healthcare will depend on nitric oxide product technology is supported by significant scientific evidence highlighting the critical role of nitric oxide (NO) in human health. Nitric oxide is a signaling molecule that plays a crucial role in various biological processes, including blood flow regulation, oxygen delivery, and immune function[1][2]. Here's a detailed assessment of the claim based on trends in health technology and therapeutic research:

### Role of Nitric Oxide in Health

1. **Biological Functions**: Nitric oxide acts as a vasodilator, improving blood flow and circulation, and has anti-inflammatory properties[1]. It also plays a role in killing pathogens and acts as a neurotransmitter[1].

2. **Disease Prevention and Treatment**: Nitric oxide deficiency has been linked to various chronic conditions such as hypertension, erectile dysfunction, and potentially Alzheimer's and diabetes[1]. Its deficiency, which can start as early as age 30, is considered a precursor to many age-related diseases[1].

3. **Current Therapeutic Applications**: Inhaled nitric oxide is FDA-approved for treating pulmonary hypertension in newborns and is used in other respiratory conditions[5]. Research is ongoing to explore its potential in treating neurodegenerative disorders and infectious diseases[5].

### Trends in Nitric Oxide Technology

1. **Advancements in Delivery Systems**: Innovations like Beyond Air's LungFit system, which generates NO from room air, are revolutionizing the delivery of nitric oxide therapy, making it more accessible and efficient[4].

2. **Research and Development**: There is a significant focus on developing new NO-based therapies, including NO-releasing platforms and drugs that enhance NO production or availability[2][3]. These developments aim to address the challenges of delivering a bioactive gas like NO effectively.

3. **Market and Pharmaceutical Interest**: The pharmaceutical market for NO-based therapies is substantial, with many companies investing in NO-related research and development[2].

### Validity of the Claim

Given the extensive research and the critical biological roles of nitric oxide, it is reasonable to conclude that nitric oxide technology holds significant promise for the future of medicine and healthcare. The claim is supported by:

– **Scientific Evidence**: Nitric oxide's role in preventing and treating chronic diseases is well-documented[1][2].
– **Technological Advancements**: Innovations in NO delivery systems and ongoing research in NO-based therapies are transforming healthcare[4][3].
– **Pharmaceutical Interest**: The substantial investment in NO-related research indicates its potential impact on future healthcare strategies[2].

However, while nitric oxide is a crucial molecule with vast therapeutic potential, it is unlikely to be the sole determinant of the future of medicine. Instead, it will likely be one of many important technologies and therapeutic approaches that shape healthcare advancements.

In summary, the claim that the future of medicine and healthcare will depend on nitric oxide product technology is valid in the context of its potential to significantly impact healthcare through its therapeutic applications and ongoing research. However, it should be considered as part of a broader landscape of medical advancements rather than the sole future direction.

Citations

Claim

If you have a hemoglobin A1C of greater than 5.7, you're diabetic.

Veracity Rating: 0 out of 4

Facts

The claim that having a hemoglobin A1C (HbA1c) level greater than 5.7% indicates diabetes is **incorrect**. According to established medical guidelines, an HbA1c level of 5.7% to 6.4% is considered **prediabetes**, not diabetes. Diabetes is diagnosed when the HbA1c level is **6.5% or higher**[3][5].

Here is a summary of the HbA1c ranges for diagnosing diabetes and prediabetes:

– **Normal**: Below 5.7%
– **Prediabetes**: 5.7% to 6.4%
– **Diabetes**: 6.5% or above[3][5].

The HbA1c test measures the average blood glucose levels over the past 3 months and is widely used for diagnosing and managing diabetes[3][5]. It is essential to understand these thresholds to accurately interpret HbA1c results and to avoid misdiagnosis.

In the context of Dr. Nathan Bryan's work on nitric oxide, while his research focuses on the role of nitric oxide in health and disease, it does not directly relate to the diagnostic criteria for diabetes based on HbA1c levels. Therefore, the claim about HbA1c levels and diabetes diagnosis should be evaluated independently of Dr. Bryan's research on nitric oxide.

Citations

Claim

Diabetics have a 10 times higher incidence of heart attack and stroke.

Veracity Rating: 1 out of 4

Facts

## Evaluating the Claim: Diabetics Have a 10 Times Higher Incidence of Heart Attack and Stroke

To assess the claim that diabetics have a 10 times higher incidence of heart attack and stroke, we need to examine epidemiological studies and data on the relationship between diabetes and cardiovascular disease (CVD).

### Relationship Between Diabetes and Cardiovascular Disease

Diabetes is recognized as a significant risk factor for cardiovascular diseases, including heart attacks and strokes. The American Heart Association notes that people with Type 2 diabetes are more likely to develop and die from cardiovascular diseases compared to those without diabetes[2]. However, the exact risk multiplier can vary based on several factors, including the presence of other risk factors such as high blood pressure, abnormal cholesterol levels, obesity, and lack of physical activity[2][4].

### Incidence of Heart Attack and Stroke in Diabetics

While diabetes significantly increases the risk of cardiovascular events, stating that diabetics have a "10 times higher incidence" of heart attacks and strokes may not accurately reflect the complexity of this relationship. Studies indicate that individuals with diabetes have a risk of cardiovascular events that is two to four times higher for heart disease and two to six times higher for stroke compared to those without diabetes[4]. This does not necessarily equate to a uniform "10 times higher" risk across all populations.

### Nitric Oxide and Cardiovascular Health

Nitric oxide plays a crucial role in cardiovascular health by relaxing blood vessels and improving blood flow[1][3]. A deficiency in nitric oxide can lead to conditions such as hypertension and impaired blood flow, which are risk factors for cardiovascular disease[3]. However, while nitric oxide is important for overall cardiovascular health, its direct impact on the specific risk multiplier for heart attacks and strokes in diabetics is not explicitly quantified in the available literature.

### Conclusion

The claim that diabetics have a "10 times higher incidence" of heart attack and stroke is not supported by the available scientific evidence. While diabetes does significantly increase the risk of cardiovascular events, the risk is generally reported as being two to four times higher for heart disease and two to six times higher for stroke[4]. Therefore, the claim appears to be an overstatement based on current epidemiological data.

**Recommendation for Future Claims:**
– When making claims about health risks, it is crucial to rely on precise data from reputable sources.
– The relationship between diabetes and cardiovascular disease is complex and influenced by multiple factors, making it important to consider these nuances when discussing risk.

**Additional Information:**
– Dr. Nathan Bryan's work highlights the importance of nitric oxide in health, but his findings do not directly address the specific risk multiplier for heart attacks and strokes in diabetics.
– Maintaining adequate nitric oxide levels through diet and lifestyle can contribute to overall cardiovascular health, but this does not directly validate the claim about the incidence of heart attacks and strokes in diabetics.

Citations

Claim

Sugar destroys the oral microbiome and completely changes the ecology of the bacteria.

Veracity Rating: 2 out of 4

Facts

## Claim Evaluation: Sugar Destroys the Oral Microbiome and Completely Changes the Ecology of the Bacteria

The claim that sugar destroys the oral microbiome and completely changes the ecology of the bacteria warrants a thorough examination of scientific evidence. Recent studies have indeed shown that high sugar intake can significantly impact the oral microbiome, but the extent of this impact needs clarification.

### Impact of Sugar on Oral Microbiome

1. **Diversity and Balance**: Research indicates that sugar-rich diets have an unfavorable effect on the diversity and balance of oral microbiota. Studies have shown a significant decrease in microbial diversity with high sugar intake, leading to the predominance of certain bacteria such as *Streptococcus*, *Scardovia*, *Veillonella*, *Rothia*, *Actinomyces*, and *Lactobacillus* [1][2].

2. **Cariogenic Bacteria**: High sugar consumption is associated with an increase in cariogenic bacteria, which convert sugars into acids harmful to teeth. This process disrupts the oral microecology and can lead to dental caries [3][5].

3. **Salivary Microbiome**: Sugary drinks have been found to alter the salivary microbiome, reducing bacterial richness and increasing the abundance of acid-producing bacteria. This can lead to oral diseases like periodontitis and may have broader health implications [5].

### Nitric Oxide Production and Oral Microbiome

While there is substantial evidence linking sugar intake to changes in the oral microbiome, the specific relationship between sugar consumption, oral microbiome health, and nitric oxide production is less clear. Nitric oxide plays a crucial role in vascular health and is involved in various physiological processes, but direct research connecting sugar intake and nitric oxide levels through the oral microbiome is not well-documented in the provided sources.

### Conclusion

The claim that sugar destroys the oral microbiome and completely changes its ecology is partially supported by evidence showing that high sugar intake negatively affects oral microbiota diversity and promotes cariogenic bacteria. However, the statement might be overstated, as it suggests a complete destruction of the oral microbiome, which is not explicitly documented in the literature. Further research is needed to fully understand the impact of sugar on the oral microbiome and its potential effects on nitric oxide production.

### Recommendations for Future Research

1. **Detailed Mechanisms**: Investigate the precise mechanisms by which sugar intake affects the oral microbiome and whether these changes have a direct impact on nitric oxide production.

2. **Longitudinal Studies**: Conduct longitudinal studies to assess the long-term effects of sugar consumption on oral microbiota and overall health outcomes.

3. **Interdisciplinary Approaches**: Employ interdisciplinary research combining microbiology, nutrition, and cardiovascular health to explore potential links between sugar intake, oral microbiome health, and nitric oxide levels.

Citations

Claim

75% of Americans are deficient in magnesium and 95% of Americans are deficient in iodine.

Veracity Rating: 0 out of 4

Facts

The claim that **75% of Americans are deficient in magnesium** and **95% of Americans are deficient in iodine** can be evaluated based on available scientific and nutritional studies.

## Magnesium Deficiency

– **Prevalence**: Studies indicate that a significant portion of the U.S. population does not meet the recommended daily intake of magnesium. Approximately **40% to 50%** of Americans consume less than the Estimated Average Requirement (EAR) for magnesium[2][4]. This suggests that while a substantial number of Americans may be at risk of magnesium deficiency, the figure is not as high as 75%.

– **Evidence**: The U.S. Department of Agriculture reports that the average magnesium intake in women and men is 228 mg/day and 323 mg/day, respectively, which is below the recommended levels for many individuals[2]. However, there is no evidence to support a 75% deficiency rate.

## Iodine Deficiency

– **Prevalence**: Iodine deficiency is a significant global health issue, but in the United States, the situation is different. While iodine intake has decreased over the years, the U.S. population is generally considered iodine sufficient[1][5]. However, certain subgroups, such as pregnant women and women of reproductive age, may be at higher risk of iodine deficiency[3][5].

– **Evidence**: NHANES data from 2011–2014 indicate that the median urinary iodine concentration (UIC) for the U.S. population aged 6 years and older was 133 µg/L, which is within the adequate range for non-pregnant adults[3]. Approximately **38%** of the U.S. population had a UIC below 100 µg/L, indicating insufficient iodine intake[3]. This does not support a claim of 95% deficiency.

## Conclusion

The claims that **75% of Americans are deficient in magnesium** and **95% of Americans are deficient in iodine** are not supported by current scientific evidence. While there are significant deficiencies in both nutrients among certain segments of the population, the overall prevalence rates are lower than those claimed. For magnesium, approximately 40% to 50% of Americans may not meet the recommended intake, and for iodine, about 38% of the population may have insufficient intake based on UIC levels. Therefore, these claims appear to be exaggerated based on available data.

Citations

Claim

There is a quadrupling in the use of antacid medications from 2004 over a 20 year period.

Veracity Rating: 1 out of 4

Facts

To evaluate the claim of a quadrupling in the use of antacid medications from 2004 over a 20-year period, we need to examine pharmaceutical sales data and market trends for antacids during this time frame.

## Analysis of the Claim

1. **Pharmaceutical Sales Data**: The claim about a quadrupling in antacid usage suggests a significant increase in sales or consumption. However, specific sales data from 2004 to 2024 is not readily available in the provided sources.

2. **Market Trends**: The global antacids market has indeed grown, driven by factors such as increased gastrointestinal disorders, lifestyle changes, and consumer awareness of over-the-counter remedies[1][2]. The market was valued at approximately $6.8 billion in 2023 and is projected to reach $7.9 billion by 2030, indicating a growth trend but not specifically a quadrupling over the past 20 years[1].

3. **Consumer Behavior and Health Trends**: The rise in antacid use can be linked to dietary habits, stress, and an aging population, which are common factors contributing to gastrointestinal issues[1][2]. However, these factors alone do not provide concrete evidence of a quadrupling in usage.

## Conclusion

While there is evidence of growth in the antacids market due to various health and lifestyle factors, there is no specific data in the provided sources to confirm a quadrupling in the use of antacid medications from 2004 to 2024. To validate this claim, detailed historical sales data or consumption patterns would be necessary.

## Recommendations for Further Research

– **Historical Sales Data**: Accessing historical sales figures or market research reports from reputable sources like pharmaceutical companies or market research firms could provide more precise insights into the trend of antacid usage over the past two decades.
– **Consumer Surveys and Studies**: Analyzing consumer surveys or studies on antacid usage could offer additional insights into how consumption patterns have changed over time.
– **Healthcare Trends**: Examining broader healthcare trends, such as the prevalence of gastrointestinal disorders and changes in healthcare policies, might also shed light on the factors influencing antacid use.

Citations

Claim

Nasal breathing activates enzymes that make nitric oxide and dilates bronchioles and pulmonary arteries.

Veracity Rating: 3 out of 4

Facts

## Claim Evaluation: Nasal Breathing Activates Enzymes That Make Nitric Oxide and Dilates Bronchioles and Pulmonary Arteries

The claim that nasal breathing activates enzymes that produce nitric oxide (NO) and dilates bronchioles and pulmonary arteries can be evaluated based on scientific evidence related to nitric oxide production and its physiological effects.

### Nitric Oxide Production and Nasal Breathing

1. **Nitric Oxide Production in the Nasal Cavity**: Nitric oxide is produced in the nasal cavity and sinuses by the enzyme nitric oxide synthase (NOS) [3][5]. Nasal breathing can increase the concentration of NO in the upper airways, as it is a primary source of exhaled NO [1][5].

2. **Effect of Nasal Breathing on NO Levels**: Nasal breathing techniques, such as humming and controlled breath holding, can enhance NO production [1]. Humming, for instance, can increase NO levels up to 15-fold compared to quiet breathing [1].

### Physiological Effects of Nitric Oxide

1. **Vasodilation**: Nitric oxide is a potent vasodilator, meaning it can dilate blood vessels, including pulmonary arteries. This effect is crucial for regulating blood flow and oxygen delivery to tissues [4].

2. **Bronchodilation**: NO also acts as a bronchodilator, helping to relax bronchial smooth muscle and improve airway patency [4]. This is particularly relevant in conditions like asthma, where airway constriction is a significant issue.

### Relationship Between Nasal Breathing and Pulmonary Effects

While nasal breathing increases NO production, which can contribute to vasodilation and potentially improve pulmonary function, there is no direct evidence that nasal breathing alone significantly dilates bronchioles and pulmonary arteries in healthy individuals. However, the increased NO levels from nasal breathing could contribute to these physiological effects indirectly by improving overall respiratory health and function.

### Conclusion

The claim that nasal breathing activates enzymes to produce nitric oxide is supported by evidence showing that nasal breathing increases NO levels in the upper airways. However, the specific assertion that this directly dilates bronchioles and pulmonary arteries requires more direct evidence. Nitric oxide's role in vasodilation and bronchodilation is well-established, but the extent to which nasal breathing alone achieves these effects in the lower respiratory tract is less clear.

In summary, while nasal breathing does enhance NO production, which is beneficial for overall respiratory health, the direct impact on bronchiole and pulmonary artery dilation needs further clarification. Dr. Nathan Bryan's emphasis on the importance of nitric oxide in health aligns with scientific understanding, but specific claims about nasal breathing's effects on the lower respiratory tract should be approached with caution until more direct evidence is available.

Citations

Claim

Certain frequencies of humming can activate the nitric oxide synthase enzyme.

Veracity Rating: 0 out of 4

Facts

## Evaluation of the Claim: Certain Frequencies of Humming Can Activate the Nitric Oxide Synthase Enzyme

The claim that certain frequencies of humming can activate the nitric oxide synthase enzyme is intriguing and suggests a potential interaction between sound frequencies and biochemical processes. However, to validate this claim, we need to examine existing research on the effects of sound frequencies on biochemical processes, particularly those involving nitric oxide synthase.

### Nitric Oxide Synthase and Its Importance

Nitric oxide synthase (NOS) is an enzyme responsible for producing nitric oxide (NO), a crucial signaling molecule involved in various physiological processes, including vascular health, immune function, and neurotransmission[1][3]. Dr. Nathan Bryan's work emphasizes the importance of nitric oxide in human health, highlighting its role in preventing diseases like Alzheimer's and diabetes[3][5].

### Effects of Sound Frequencies on Biochemical Processes

While there is substantial research on the effects of sound on psychological and physiological states, specific studies on how sound frequencies directly influence nitric oxide synthase activity are limited. Most research in this area focuses on the broader impacts of sound on stress reduction, mood enhancement, and potential therapeutic benefits. However, there is no widely recognized scientific evidence directly linking humming frequencies to the activation of nitric oxide synthase.

### Potential Mechanisms and Future Research Directions

To validate the claim, future research could explore several potential mechanisms:
1. **Vibration and Cellular Response**: Sound vibrations might influence cellular processes, potentially affecting enzyme activity. Research could investigate how different frequencies might interact with cellular structures to modulate enzyme function.
2. **Stress Reduction and Nitric Oxide**: Since stress can impact nitric oxide levels, sound therapy (including humming) might indirectly influence nitric oxide production by reducing stress. Studies could examine whether stress reduction through sound therapy correlates with increased nitric oxide levels.
3. **Neurological Effects**: Sound frequencies could have neurological effects that indirectly influence nitric oxide production. For example, if certain frequencies enhance neural activity related to nitric oxide regulation, this could be a pathway for influencing nitric oxide synthase.

### Conclusion

Currently, there is no direct scientific evidence supporting the claim that certain frequencies of humming can activate the nitric oxide synthase enzyme. While Dr. Nathan Bryan's work highlights the importance of nitric oxide in health, and there is interest in how sound frequencies might affect biological processes, specific research on this topic is needed to validate the claim. Future studies should focus on the potential mechanisms by which sound frequencies could influence biochemical processes, including the activation of enzymes like nitric oxide synthase.

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**References:**

[1] Wikipedia. (n.d.). Nathan Bryan (scientist). Retrieved from https://en.wikipedia.org/wiki/Nathan_Bryan_(scientist)

[2] University of Newcastle. (n.d.). Professor Ravi Naidu. Retrieved from https://www.newcastle.edu.au/profile/ravi-naidu

[3] YouTube. (2023). Nitric Oxide and Functional Health – with Dr. Nathan Bryan. Retrieved from https://www.youtube.com/watch?v=AU3Fp7R11KQ

[4] MDPI. (n.d.). Benefits of the Mediterranean Diet–Wine Association. Retrieved from https://mdpi-res.com/bookfiles/book/5432/Benefits_of_the_Mediterranean_DietWine_Association_Role_of_Components.pdf

[5] American Dental Association. (n.d.). Nathan S. Bryan Ph.D. Retrieved from https://engage.ada.org/b/sp/nathan-bryan-395

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**Note:** The search results do not provide specific evidence linking humming frequencies to the activation of nitric oxide synthase. Therefore, the claim remains unsubstantiated by current scientific literature.

Citations

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